Brian Till, MD

Dr. Brian Till develops new treatments for lymphoma by genetically engineering a patient's own T cells so they can more effectively attack cancer. T cells target and kill cancer cells by binding to specific proteins on the tumor cells with molecules called T-cell receptors. Dr. Till's research involves making synthetic receptors known as chimeric antigen receptors, or CARs, that home in on lymphoma cells. He led the first published trial testing CAR T cells as a treatment for lymphoma patients. Dr. Till continues to carry out a variety of immunological, genetic and gene-expression studies in the clinic to understand why CAR T-cell therapies work for some patients and fail for others. This research will help improve the next iterations of this experimental therapy.