When to do what to reduce your risk of cancer

A handy decade-by-decade guide for recommended screenings and other preventive actions
Illustration of a person walking up steps surrounded by icons symbolizing healthy behaviors
Confused about when to get screened for what? Wondering what matters most for long-term good health? Fred Hutch experts break down the basics, decade by decade. Illustration by Stephanie Liszewski / Fred Hutch News Service


It’s a new year — again! — and everyone you know is doing dry (or damp) January, joining gyms and talking about mindfulness. Unfortunately, by the end of the month, their resolve may start to dwindle.

That’s because good health habits aren’t just for January — they’re for every day. And the earlier you start leaning into them, the better off you’ll be by the time you get to the late December of your life. Having said that, it’s never too late to jump on the good old health horse.

Where to start, though? Rummaging in the closet for your tennis racket or running shoes is a great place to begin (exercise is medicine, after all), but there are plenty of other behaviors that can help you stay healthy and happy for decades to come.

One of the simplest is making sure you’re getting regular cancer screenings. We’ve compiled guidelines for those cancers that can be caught early via screening or scans, breaking it all down decade by decade so you can see when you need to start thinking about testing for breast, cervical, colorectal, lung or prostate cancers and when you can stop.

Several national organizations produce cancer screening recommendations and Fred Hutchinson Cancer Center’s researchers often serve on their screening committees. We’ve cited guidelines from the American Cancer Society, or ACS, and the U.S. Preventive Services Task Force, or USPSTF. Guidelines for these two organizations are updated every few years (some guidelines cited here are mid-update).

Of course, cancer prevention is more than just early detection through scans and screenings. So, we’ve also folded in additional information on what you can do, decade by decade, to continue to live your most healthy life. The following list is by no mean complete, but it should keep you on the right track. Following these steps might even help you avoid other common chronic diseases.

“Many of the steps you can take to reduce your risk of cancer have the added benefit of helping to reduce your risk of cardiovascular disease, diabetes and possibly even dementia,” said Garnet Anderson, PhD, senior vice president and director of Fred Hutch’s Public Health Sciences Division and holder of the Fred Hutch 40th Anniversary Endowed Chair. “There are plenty of reasons to make these changes.”


Reducing your risk of cancer: A decade-by-decade guide

Ages 10 to 20

Cancer prevention for the far future

It’s not always possible to prevent cancer, but the sooner you can start incorporating healthy behaviors into your life, the better your chances are of sidestepping cancer later down the line. Starting early absolutely gives you a leg up.

Get vaccinated. Numerous cancers — cervical, anal, penile, vulvar, throat, mouth and others — are preventable by vaccinating against human papillomavirus, or HPV. Most human beings are infected with HPV during their life and per the World Health Organization, around 625,600 women and nearly 70,000 men are diagnosed with an HPV-related cancer each year. Vaccination prevents 90% of these cancers. Fred Hutch’s Denise Galloway, PhD, helped pave the way for the HPV vaccine. She holds the Paul Stephanus Memorial Endowed Chair and is scientific director of the Pathogen-Associated Malignancies Integrated Research Center. The Centers for Disease Control and Prevention, or CDC, recommends all children complete HPV vaccination by age 11 or 12 (they can start as early as age 9). 

Don’t smoke. Highly addictive commercial tobacco products have been linked to numerous cancers (not just lung) and if you don’t start or are able to quit, you’ll lower your risk of 12 cancers and glean numerous other health benefits. Vaping, too, holds risk; ditto for chewing tobacco. Already smoking/chewing/vaping? Fred Hutch’s Jonathan Bricker, PhD, has developed a suite of smartphone apps to help overcome nicotine cravings. His team’s QuitBot app is free to the public.

Avoid tanning. It may feel glorious to soak up the sun, but indulging too much when you’re young bumps your skin cancer risk. Cover up and/or use sunscreen — especially in these tender years — to cut that risk. Melanoma, the most deadly skin cancer, is caused by UV exposure, via the sun and via tanning beds, and it’s strongly linked to childhood sunburn. “In the Northwest we often forget about sun protection,” said public health researcher Marian Neuhouser, PhD, RD. “Wear a hat and use sun protection when outdoors whether you’re walking, hiking, skiing, snowboarding or gardening.” Neither the USPSTF or the ACS have screening recommendations for skin cancer, but many doctors recommend checking your skin regularly for any new or changing growths, spots or bumps. In addition, the FDA just approved an AI-powered device to detect skin cancer. ACS also offers these sun safety tips. Slather on!

Gather your family’s health history. Another way to proactively reduce your risk of cancer is to know your family health history. The CDC recommends collecting family history of cancer and sharing it with your doctor. Those with a family history of breast, ovarian, pancreatic, prostate or other cancers may have a genetic mutation such as BRCA1/2, ATM, TP53, PALB2 (there are others) that puts them at higher risk. If that’s you, talk to your doctor about genetic testing and counseling and whether you might need early cancer screenings. More information on inherited cancers is available from the NCI, the ACS and the USPSTF. Still have questions? Contact Fred Hutch’s Clinical Genetics and Genetic Counseling Service.

Get screened. If you do have a risk for inherited cancer, you may need to start screening for cancer even at a young age. There are no national recommendations for breast, lung or prostate cancer screening for those under 40, but the ACS does mention people at high risk for inherited colorectal cancer may need to undergo colonoscopy screening as early as their teenage years.

Watch the alcohol. Yes, these are the high school and college years. But groups like the IARC, International Agency for Research on Cancer, classify alcohol as a potent carcinogen, linked to oral, pharyngeal, laryngeal, esophageal, liver, colorectal and breast cancers. The WHO has also stated there is “no safe amount of alcohol consumption” when it comes to cancer. News everybody can use, no matter your age.

Be active. “Exercise is the one reliable thing people can do to decrease cancer risk,” said Fred Hutch epidemiologist and internist Anne McTiernan, MD, PhD, who studies the health benefits of exercise. And the NCI agrees, emphasizing that there’s “strong evidence that higher levels of physical activity are linked to lower risk of several types of cancer.” Even kids, McTiernan said, should be active at least one hour a day, whether in school, sports or family activities. Adults need exercise, too! Read on for exercise recommendations as you age.

Illustration of healthy fruits and vegetables
Plant-based food sources like whole grains, beans, fruits and vegetables contain phytonutrients which have natural cancer-preventive and anti-inflammatory properties. “This helps promote immune function and helps promote cellular repair,” said Dr. Heather Greenlee, medical director of Fred Hutch’s Integrative Medicine Program. Illustration by Stephanie Liszewski / Fred Hutch News Service

Ages 20 to 30 

Building a foundation for good health

All of the above tips apply for this age group. And since these are the years when many people have small children, you may want to pay special attention to both your good and bad behaviors since they will definitely influence the actions of your little ones.   

Quit for your kids. Research by smoking cessation expert Bricker on children whose parents quit smoking when the kids were young found those kids were much less likely to smoke by high school. If both parents quit, the child's odds of becoming a smoker dropped by 40%. 

Lean towards green. If you’re hoping for a long, healthy life, lean towards a plant-based diet. When you choose more plant sources than meat or dairy sources, you benefit from phytonutrients which have natural cancer-preventive and anti-inflammatory properties. “This helps promote immune function and helps promote cellular repair,” said Heather Greenlee, ND, PhD, MPH, medical director of Fred Hutch’s Integrative Medicine Program. Plants are also loaded with fiber — good for both our digestive tract and our gut microbiome, which supports our immune system; cruciferous veggies like broccoli, kale, radishes and Brussels sprouts actively fight cancer. Learn more about healthy eating at Fred Hutch’s Cook for Your Life.

Think “weight management.” Being overweight or obese increases risk for 13 different cancers, thanks to increased inflammation, higher levels of insulin and the additional estrogen in fat tissue, among other reasons. The CDC classifies overweight as having a BMI from 25.0 to 29.9; obesity is classified as a BMI of 30.0 or higher. Unsure how to start eating better? US News & World Report just ranked their top diets which includes the Mediterranean and the heart-healthy DASH diet. McTiernan and Neuhouser also recommend the Diabetes Prevention Program diet, which was designed and tested in diverse populations, has been shown to work well for weight loss (with exercise) and may be more affordable.

Be mindful of what you eat. Neuhouser said "whenever possible, cook meals from ingredients instead of eating pre-made or packaged foods. Also, make meals colorful.” She also recommended limiting extra sugar from sugar-sweetened beverages, breakfast cereals and desserts. Neuhouser — along with many national and international organizations —also recommends limiting red and processed meat such as hot dogs, sausage, cold cuts and, yes, even bacon.

Get screened. Again, the ACS and USPSTF have no recommendations for breast, lung or prostate cancer screening for average risk people under 40, however there are recommendations for cervical cancer screening. ACS recommends people receive an HPV test every five years starting at age 25. USPSTF recommends a Pap smear every 3 years for those age 21 to 29. Unvaccinated for HPV? Talk with your doctor. Cancer in your family? Genetic mutation found? Your screenings may start earlier.

Stay active. Again, this is key for good health throughout your life. “Adults should strive for at least 150 minutes a week of moderate level activity or greater,” McTiernan said. But there’s no need to be an all-out athlete. “People can reduce cancer risk with ordinary movement like walking,” she said. “Being active helps stave off weight gain over the years — it's not a miracle for weight loss, but it helps. Exercise also reduces risk for several types of cancer including the most common ones like breast and colorectal cancers.” There’s also this from a Healthline interview with an ACS spokesperson: “We don’t know the exact, optimal dose of exercise needed for cancer prevention. But we know from the evidence to date that the more you do the better.” 

Get those ZZZZZs. “We have much more control over our sleep than we do family history of cancer,” said Fred Hutch public health researcher Amanda Phipps, PhD, MPH. “Research generally suggests the more attention we give to sleep as an important aspect of overall health, the better.” Research by Fred Hutch also links good sleep with better outcomes in some cancer patients. Don’t scrimp on sleep!

Fred Hutch's Dr. Garnet Anderson
“Many of the steps you can take to reduce your risk of cancer have the added benefit of helping to reduce your risk of cardiovascular disease, diabetes and possibly even dementia,” said Dr. Garnet Anderson, senior vice president and director of Fred Hutch’s Public Health Sciences Division.

Ages 30 to 40

Staying the course into adulthood

Not smoking, watching your weight and regular exercise are all advised for those in their 30s, as well, along with watching alcohol intake, not sitting for hours on end and making sure you know your family’s history of cancer so you’re getting any necessary (early) screenings. You may also want to pay special attention to your mental health during these stressful career-building years.

Watch the stress. Exercise, of course, is a great way to destress (and improve your mood!); even better, it helps keep cancer at bay. Research also shows spending time in green spaces (such as forests, parks, grasslands and recreational areas) as well as blue spaces (rivers, oceans and lakes) improve our overall health and wellbeing. Nature can be an important resource for those dealing with cancer, as well.

Keep moving that body. ACS advises adults to get at least 150-300 minutes of moderate-intensity physical activity or 75-150 minutes of vigorous-intensity activity (or a combo of both) per week. And feel free to go overboard. More is better when it comes to being active. Exercise is especially important if you’re trying to counteract sedentary behavior, like sitting at a desk all day. Read more on how being active prevents disease.

Know your risks. ACS keeps an ongoing list of known and probable human carcinogens, but they’re quick to note carcinogens alone don’t cause cancer all the time, in all circumstances. Sometimes, your genetic makeup coupled with an exposure — say, smoking or heavy drinking — creates a cancer. If you live in an area with a lot of air pollution (or seasonal wildfire smoke), consider getting an air purifier. Also of note are chemicals used in beauty products. The FDA, for instance, has proposed a ban on formaldehyde in hair relaxers and other hair products used by many Black women. 

Get screened. ACS and USPSTF have no recommendations for breast, lung or prostate cancer screening for average risk people under 40, but ACS recommends cervical cancer screening via an HPV test every five years for those age 25 to 65. USPSTF recommends a Pap smear every 3 years or an HPV test (or both) every 5 years for people ages 30 to 65. As for colorectal cancer screening, if you’re at higher risk, you may need screenings earlier. Please note, colorectal cancer rates are increasing in young people so definitely know your family history and don’t dismiss changes in your health or bowel habits. Cancer in your family? Genetic mutation found? Your screenings may start earlier.

Illustration of running shoes, sunscreen, a small dumbbell and a tree symbolizing healthy behaviors.
“Exercise is the one reliable thing people can do to decrease cancer risk,” said Fred Hutch epidemiologist and internist Dr. Anne McTiernan, who studies the health benefits of exercise. Illustration by Stephanie Liszewski / Fred Hutch News Service

Ages 40 to 55

Maintaining through middle age

Our risk for cancer increases as we get older — cancer is a disease of aging, after all — so it makes sense that screening guidelines become much more nuanced as we age. Questions about screening for other cancers? The NCI’s Cancer Information Service, reachable at 1-800-4-CANCER, is available to answer any and all queries, 9 a.m. to 9 p.m. ET Monday through Friday.

Keep up with these screenings. More importantly, make sure you follow-up with your providers if necessary.

  • Breast cancer. According to the ACS, average risk folks should start getting regular annual mammograms starting at age 45, but they should have opportunity to begin annual screening at age 40. The USPSTF recommends mammograms every other year from ages 40-74.
  • Cervical cancer. The ACS recommends an HPV test every five years from age 25 to 65. The USPSTF recommends a Pap smear every 3 years or an HPV test (or both) every 5 years for people 30 to 65.
  • Colorectal cancer. The ACS recommends average risk folks to start screening yearly with an at-home FIT kit or every 10 years with colonoscopy from age 45 to 75. Those at higher risk for should receive colonoscopies every 1 to 3 years. The USPSTF recommends screening for all adults aged 50 to 75 years (annually with a FIT kit and every 10 years for colonoscopy).
  • Lung cancer. Neither ACS nor USPSTF recommend screening for people under 50. Over 50? Check the recommendations in the next section.
  • Prostate cancer. Those at the very highest risk should ask about screening at age 40, per ACS; African American men and others at risk should ask at age 45. Average risk men should ask their doctor about screening at 50. USPSTF offers no prostate screening recommendations until age 55.
  • As always, those at high risk due to a family history or known genetic mutation may start cancer screenings much earlier.

Know your risks. Again, it’s important to keep additional cancer risks in mind, from air pollution and its particulate matter (get an air purifier!) to a diet full of unhealthy fried food (eat more whole grains and veggies!) to chemicals that may influence your body in different ways. Menopause is happening for many women in this age group. If symptoms are overwhelming, hash out the risks and benefits of hormone therapy with your doctor. Keep active (including strength training), stay social, don’t smoke and talk to your doctor about what else you can do. 

Illustration of a family tree, a prescription bottle and cancer screening reminders.
Our risk for cancer increases as we age, so keeping up with screening is key. If you have a family member with cancer or have a higher risk for other reasons, your cancer screenings may start earlier. Illustration by Stephanie Liszewski / Fred Hutch News Service

Ages 55 to 70

Healthy investments pay off

You know the drill by now. Move more, eat less. Get your sleep and de-stress with walks, social time with friends and family and hobbies and/or creative pursuits. Follow up on any weird symptoms (or abnormal tests/scans). And don’t ignore your gut. If something seems amiss, talk to your doctor about it. While you’re there, maybe get a bone scan. And a shingles shot!

Screening for cancer remains key. Ditto for those follow-up appointments, if recommended.

  • Breast cancer. The ACS recommends women over 55 get mammograms every other year, or yearly, depending on preference; the USPSTF recommends women get mammograms every other year from ages 40-74.
  • Cervical cancer. ACS recommends an HPV test every five years from age 25 to 65. After 65, it’s unnecessary for low-risk individuals. USPSTF recommends a Pap smear every 3 years or an HPV test (or both) every 5 years for people ages 30 to 65.
  • Colorectal cancer. ACS recommends those at average risk get screened yearly with a FIT kit or every 10 years with colonoscopy until age 75. Higher risk individuals should get colonoscopies every 1 to 3 years. USPSTF recommends colorectal screening for all adults aged 50 to 75 years — annually with a FIT kit and every 10 years for colonoscopy.
  • Lung cancer. ACS and USPSTF both recommend people aged 50 to 80 who smoke or used to smoke at least a pack a day for 20 years (or 2 packs a day for 10 years) receive a yearly low-dose CT scan to look for lung cancer.
  • Prostate cancer. Men with the highest risk, should ask about screening at age 40, per ACS; African American men and those at higher risk should ask at age 45. Average risk men should ask about screening at age 50. The USPSTF recommends men up to age 69 talk over the harms and benefits of screening with their doctor and undergo PSA testing based on individual preference. 

Ages 70 to 80 and beyond

Keep going through the home stretch

How’s your hearing? Your eyesight? Your mobility? Do you still have a strong circle of friends? Are you up to date on all your vaccinations? Staying active, spending quality time away from screens, adequate sleep and a focus on real ingredients (as opposed to calorie rich and processed CRAP) will all continue to serve you well in your 70s, 80s and beyond. Your cancer screenings may be reduced during this time, so talking to your doctor about concerning symptoms is crucial.

Healthy? Keep getting screened.

  • Breast cancer. ACS recommends mammograms every other year, or yearly, depending on preference and general health; the USPSTF recommends women get mammograms every other year until age 74.
  • Cervical cancer. No screening is recommended after age 65 by ACS or USPSTF for low-risk individuals.
  • Colorectal cancer. ACS recommends average risk folks continue to get screened yearly via FIT kit or every 10 years via colonoscopy until age 75. After that, it’s based on life expectancy, history and overall health. After age 85, ACS does not recommend screening. Higher risk individual? Check with your doctor about screening recommendations. USPSTF recommends “selective” screening for colorectal cancer in adults aged 76 to 85 years, as needed.
  • Lung cancer. ACS and USPSTF both recommend people aged 50 to 80 who smoke or used to smoke at least a pack a day for 20 years (or 2 packs a day for 10 years) receive a yearly low-dose CT scan to look for lung cancer.
  • Prostate cancer. ACS does not recommend men without symptoms who have less than a 10-year life expectancy get screening, because they aren’t likely to benefit from it. Overall health status, and not age alone, is important when making decisions about screening. USPSTF recommends against PSA-based screening for prostate cancer in men 70 years and older. Fred Hutch biostatistician Ruth Etzioni, PhD, who serves on the screening guidelines committee for the American Urological Association and holds the Rosalie and Harold Rea Brown Endowed Chair, said their guidelines recommend a more “flexible” approach to screening discontinuation based on shared decision making between patient and doctor.

diane-mapes

Diane Mapes is a staff writer at Fred Hutchinson Cancer Center. She has written extensively about health issues for NBC News, TODAY, CNN, MSN, Seattle Magazine and other publications. A breast cancer survivor, she blogs at doublewhammied.com and tweets @double_whammied. Email her at dmapes@fredhutch.org. Just diagnosed and need information and resources? Visit our Patient Care page.

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Are you interested in reprinting or republishing this story? Be our guest! We want to help connect people with the information they need. We just ask that you link back to the original article, preserve the author’s byline and refrain from making edits that alter the original context. Questions? Email us at communications@fredhutch.org

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