Research

Current Research Projects

Our research focuses on the early detection and prevention of colorectal cancer through increased screening, especially among medically underserved populations. Our current projects include evaluations of novel interventions to increase adherence to colorectal cancer screening and follow-up of abnormal results.

Using a mixed-methods approach, this study aims to identify the potentially modifiable patient, provider, and system-level barriers to colonoscopy to inform interventions to improve colonoscopy completion in a safety-net population with abnormal FIT results. Analysis of qualitative patient data and finalization of a multilevel intervention are ongoing.

Learn more:

Perceptions on Barriers and Facilitators to Colonoscopy Completion After Abnormal Fecal Immunochemical Test Results in a Safety Net System
Barriers associated with inadequate follow-up of abnormal fecal immunochemical test results in a safety-net system: A mixed-methods analysis

Through stakeholder engagement, we determined the barriers and facilitators to implementing a rideshare transportation program for colonoscopy completion in a safety-net health system. A pilot of the rideshare transportation intervention to improve colorectal cancer screening and follow-up screening is ongoing.

Learn more:

Operationalizing a Rideshare Intervention for Colonoscopy Completion: Barriers, Facilitators, and Process Recommendations
Health System-Provided Rideshare Is Safe and Addresses Barriers to Colonoscopy Completion

In Western Washington, colorectal cancer mortality is highest In American Indian/Alaska Natives and Black people. We found that delays in diagnostic evaluation after presenting with symptoms suggestive of colorectal cancer alone, unlikely explains this disparity. An evaluation of surveillance colonoscopy after patients have been diagnosed and treated for colorectal cancer  that might explain this disparity is ongoing.

Learn more:

Racial Disparities in Colorectal Cancer Mortality: The Role of Endoscopy Wait-Time and Stage at Diagnosis

Recent Publications

A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening

N Engl J Med

2024 | Daniel Chung; Darrell Gray; Harminder Singh; Rachel Issaka; Victoria Raymond; Craig Eagle; Sylvia Hu; Darya Chudova; AmirAli Talasaz; Joel Greenson; Frank Sinicrope; Samir Gupta; William Grady

Implementing an Organized Colorectal Cancer Screening Program: Lessons Learned From an Academic-Community Practice

AJPM Focus

2024 | Amanda Kimura; Ari Bell-Brown; Nkem Akinsoto; Jerry Wood; Amy Peck; Victoria Feng; Rachel Issaka

Performance of OC-Auto Micro 80 Fecal Immunochemical Test in an Integrated Academic-Community Health System

J Clin Gastroenterol

2023 | Lindsey Durowoju; Patrick Mathias; Ari Bell-Brown; Nathan Breit; Hsuan-Chieh Liao; Wynn Burke; Rachel Issaka

Health System-Provided Rideshare Is Safe and Addresses Barriers to Colonoscopy Completion

Clin Gastroenterol Hepatol

2023 | Rachel Issaka; Ari Bell-Brown; Talor Hopkins; Lisa Chew; Lisa Strate; Bryan Weiner; Endoscopy Rideshare Working Group